http://dspace.ufdpar.edu.br/jspui/handle/prefix/15 2026-04-07T10:18:46Z http://dspace.ufdpar.edu.br/jspui/handle/prefix/827 Título: Impactos Da Dengue No Sistema Neurológico: Uma Análise Das Complicações Clínicas Autor(es): Carvalho, Ana Caroline Sousa; Oliveira, Vitória Alves Abstract: N/A Instituição: Universidade Federal do Delta do Parnaíba Tipo: Artigo de Periódico 2025-08-01T00:00:00Z http://dspace.ufdpar.edu.br/jspui/handle/prefix/826 Título: Anomalias Congênitas Em Parnaíba-Pi: Uma Análise Epidemiológica, Retrospectiva E De Fatores Associados Em Neonatos Autor(es): Lopes , Victor Augusto Vieira Primeiro Orientador: Canalle, Renata Abstract: Introduction: Congenital anomalies (CA) are functional, structural, or metabolic alterations that occur during intrauterine life and are identified during prenatal care or after the birth of the newborn (NB). Their etiology encompasses genetic, environmental, multifactorial, or unknown events. Factors such as maternal age, nutrition, drug abuse, acquired and genetic disorders can influence the prevalence of CA. In Brazil, data on the occurrence of CA are obtained from Live Birth Certificates (Declaração de Nascido Vivo - DNV) and stored in the Live Birth Information System (Sistema de Informações sobre Nascidos Vivos - Sinasc). Objectives: To analyze the birth prevalence of congenital anomalies in Parnaíba-PI between 2018 and 2023, characterizing them, associating cases with related factors, and conducting a retrospective investigation. Methodology: This is a cross-sectional epidemiological study approved by the Research Ethics Committee of UFDPar under protocol 6.483.843. Data collection was conducted through Sinasc using DNV, obtained from the Parnaíba-PI Health Department. Variables associated with the NB and pregnant women were analyzed within the sociodemographic and obstetric context. A case-control analysis was performed using the variables as exposure factors to calculate the Odds Ratio (OR) with a 95% confidence interval (CI) and significance level of p<0.05 using the BioEstat 5.3 software. Results: Among the 14,109 DNV, 92 presented some type of CA, with a birth prevalence of 65 per 10,000 live births. Regarding variables among NBs with CA, the sex distribution was 51.09% male, 31.52% had a birth weight <2500g, the Apgar score was <7 in 28.26% at 1 minute and 10.87% at 5 minutes, and gestational age was preterm in 29.35%. The history of abortions and other individual information was absent in the DNV. The highest frequencies of CA were in the musculoskeletal system (49.56%) and cleft lip/palate (9.73%). In the retrospective analysis, birth weight <2500g (OR=5.48; CI=3.52–8.55; p<0.0001), gestational age ≤37 weeks (OR=3.24; CI=2.05–5.13; p<0.0001), Apgar score at 1 minute (OR=9.13; CI=5.75–14.46; p<0.0001) and at 5 minutes (OR=12.20; CI=7.19–28.05; p<0.0001), and maternal education up to primary school (OR=2.89; CI=1.43–5.86; p=0.0047) were the only exposures that indicated a higher chance of birth with CA. Conclusion: It was possible to estimate the prevalence and statistically analyze the data frequencies, confirming the association of factors related to CA. However, there is a need to improve the diagnosis of CA and to train healthcare professionals for the correct completion of the DNV. The information obtained in this study is important for planning public policies focused on the care, follow-up, prevention, and quality of life of NBs with CA. Instituição: Universidade Federal do Delta do Parnaíba Tipo: Trabalho de Conclusão de Curso 2024-12-11T00:00:00Z http://dspace.ufdpar.edu.br/jspui/handle/prefix/825 Título: Eixo Microbiota-Intestino-Cérebro E O Transtorno Do Espectro Autista: Revisão Sistemática Autor(es): Guimarães , Beatriz Gonçalves Primeiro Orientador: Silva , Valécia Natália Carvalho da Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. Recent studies suggest that the gut microbiota may play a crucial role in the pathophysiology of ASD through the microbiota- gut-brain axis. This study performed a systematic review of the literature with the aim of investigating how alterations in the gut microbiota influence behavioral, cognitive, and gastrointestinal symptoms in individuals with ASD. Thirteen observational studies published between 2015 and 2025 were selected using the PubMed, Scielo, Lilacs, and ScienceDirect databases. Most studies demonstrated alterations in the microbiota composition of children with ASD, with reduced microbial diversity and increased potentially pathogenic microorganisms, such as Clostridium, Klebsiella, and Proteus. Reductions in bacteria producing butyrate, a short-chain fatty acid with anti-inflammatory and neuroprotective effects, were also observed. The findings point to a relationship between intestinal dysbiosis and changes in the metabolism of neurotransmitters, such as GABA and glutamate, in addition to an association with behavioral symptoms and gastrointestinal disorders. The influence of maternal factors, diet, and geographic location on the microbiome was also highlighted. Despite the methodological differences between the studies, the results reinforce the role of microbial imbalance in the neurobehavioral modulation of ASD. Modulation of the intestinal microbiota, through interventions such as probiotics and specific diets, appears to be a promising therapeutic approach, although more standardized and longitudinal research is needed to prove its effectiveness. Instituição: Universidade Federal do Delta do Parnaíba Tipo: Trabalho de Conclusão de Curso 2025-07-06T00:00:00Z http://dspace.ufdpar.edu.br/jspui/handle/prefix/824 Título: Chalcona Do Tipo Terpenóide Inibe Etapas-Chave Da Progressão Metastática In Vitro Em Células De Adenocarcinoma Colorretal Autor(es): Alves , Benedito Dos Santos Primeiro Orientador: Araújo, Ana Jérsia Abstract: Colorectal cancer (CRC) is among the most prevalent types of neoplasms worldwide and presents an unfavorable prognosis, mainly due to its high rate of metastasis, the leading cause of morbidity and mortality among patients. In this context, there is increasing interest in identifying new molecules capable of interfering with tumor cell dissemination. Within this framework, the synthesis of compounds based on natural products has become a strategic approach, allowing for the rational modification of bioactive structures to enhance their therapeutic effects and expand their pharmacological applicability. Chalcones and ionones have been highlighted for presenting several biological properties, including anticancer activity. Based on this perspective, the present study aimed to investigate the cytotoxic, antimigratory, and anti-adhesive effects of a terpenoid-like chalcone (BR4Cl), resulting from the structural combination of chalcone and ionone, in human colorectal adenocarcinoma cells (SW-480). Initially, the cytotoxic activity of BR4Cl was evaluated using the MTT assay, revealing IC50 values of 12.44 μM, 4.62 μM, and 3.64 μM after 24, 48, and 72 hours of treatment, respectively. Based on the 24-hour cell viability curve, subcytotoxic concentrations of 0.05 μM and 0.10 μM were established for cell adhesion and migration assays. Cell viability at these concentrations was confirmed by Trypan blue exclusion and morphological analysis using fast panoptic staining, with no significant alterations observed after 24 hours of exposure. In the clonogenic assay, BR4Cl did not significantly reduce the number or area of the colonies formed. On the other hand, the cell migration assay demonstrated that BR4Cl, at the tested concentrations, significantly inhibited the migration of SW-480 cells after 24 and 48 hours of treatment. Additionally, the cell adhesion assay indicated that BR4Cl significantly reduced cell adhesion to fibronectin, with inhibitions of 32.68% and 44.16% for 0.05 μM and 0.10 μM, respectively, after 24 hours of pretreatment. Taken together, these findings indicate that BR4Cl exhibits cytotoxic potential against CRC and is capable of interfering with critical steps in metastatic progression, such as cell migration and adhesion, in vitro. However, further studies are needed to elucidate the molecular mechanisms underlying these effects and to advance the evaluation of its therapeutic potential. Instituição: Universidade Federal do Delta do Parnaíba Tipo: Trabalho de Conclusão de Curso 2025-07-02T00:00:00Z