Influência Do Polimorfismo Rs6277 Do Gene Drd2 Em Uma População Hígida Submetida À Tarefa Cognitiva De Produção De Tempo

Abstract

Introduction: Temporal processing skill in perception of time is a crucial component for organizing daily life. Currently, perception can be assessed through tasks such as estimating, reproducing, comparing, and producing time. Dopamine is a key neurotransmitter for cognitive tasks, and single nucleotide polymorphisms (SNPs) in its receptors can alter their functionality and expression. The SNP rs6277, located in the DRD2 gene, is the focus of this study due to its association with dopaminergic system alterations linked to psychiatric disorders. Given the importance of dopamine, studies on its influence on temporal perception can elucidate how these genotypic variations may impact assessment tasks. Objective: To evaluate the influence of SNP rs6277 in a healthy male population subjected to a temporal perception activity using a time production task. Methodology: Data were collected from 122 male volunteers aged between 18 and 32 years. For the polymorphism analysis, DNA was extracted from peripheral blood and genotyped using quantitative Polymerase Chain Reaction (qPCR). Data for the time production task were obtained using specific software, where stimuli were presented to participants for the analysis of neural processing at intervals of 1, 4, 7, and 9 seconds. Data were analyzed using statistical tests: Chi-square (χ2) to verify Hardy-Weinberg Equilibrium and Kruskal-Wallis for variance analysis of behavioral data across genotypes. Results: Regarding SNP rs6277, the allele frequencies were G=60.25% and A=39.75%, and the genotype frequencies were GG=36.89%, AG=46.72%, and AA=16.39%. For behavioral data, a predominance of the overproduction profile was observed, along with differences in task execution accuracy among participants. Conclusion: Based on the obtained results, it can be concluded that there was no significant genetic influence of the dopaminergic system on the performance of the proposed temporal perception assessment task.