As consequências do uso prolongado de Ibp’s: uma revisão de literatura

Abstract

Proton Pump Inhibitors (PPIs) are widely used in the treatment of gastric disorders, but their prolonged use has been associated with several adverse effects. The methodology adopted consisted of an integrative literature review, with the search and analysis of scientific articles published between 2020 and 2025, in the PubMed and Google Academic databases. 7 studies that addressed the adverse effects of prolonged use of PPIs were selected, texts that were published before 2020, which do not include the chosen languages, that were not made available in full, that were duplicate, that were not related to review, were excluded. The selected studies show that the prolonged use of PPI's is associated with adverse events such as fractures, electrolyte disorders, vitamin B12 deficiency and chronic kidney disease. It was also evidenced that the prolonged use of PPI's is associated with adverse events such as fractures, kidney disease, gastric neoplasms, micronutrient deficiency, dementia and infections. Although effective and safe, PPIs require careful prescription and periodic reassessment to prevent risks. With the realisation of this study it was allowed to conclude that the prolonged use of PPI's, although effective, is associated with several adverse effects, such as electrolyte disorders, fractures, CKD and nutritional deficiency. Therefore, its use should be judicious, especially in at-risk patients. It is emphasised that the realisation of new studies, such as this literature review, can contribute to a continuous updating on the subject, being possible to contribute to the advances and studies in the area.